Welcome to the Genome Center

Established in 2003 the UC Davis Genome Center uses state-of-art-technologies to understand how the heritable genetic information of diverse organisms function in health and disease. The combination of cutting-edge research facilities, diverse service cores, and talented staff make the Genome Center a world class facility for genomics research and training.

Research that makes a difference

A sample of questions being addressed by the UC Davis Genome Center faculty and their collaborators:

  • How do variations in the human genome affect the risks of diseases such as cancer, coronary artery disease, and autism?
  • Do infection, diet, or stress serve as environmental triggers of Type 1 diabetes?
  • What novel, useful organisms will be discovered by sequencing microbes from extreme environments?
  • Can characterization of the small chemicals in algae lead to new biofuels?
  • How can we control diseases of important food crops?
  • How can plants be modified to increase their productivity and quality?
  • What changes can we make to proteins to enhance their performance?
  • Can we model and predict life’s basic processes?
  • How can we glean useful information from vast datasets?

News highlights

Here are just some of the recent highlights involving people and projects at the Genome Center Please see the news page for a full list of all news items.

Titus Brown’s lab joins Software Carpentry project as an affiliate member

February 2, 2015

SoftwareCarpenty_logoAssociate Professor Titus Brown joined UC Davis, and the Genome Center, in January. His Laboratory for Data Intensive Biology has now joined the Software Carpentry Foundation as an affiliate member. Software Carpentry is a volunteer organization whose goal is to make scientists more productive, ... Read more...

Updates from the DNA Technologies and Expression Analysis Cores

January 23, 2015

This is an edited summary of the January Bulletin, the full version is available on the Expression Analysis Core website.

Whole genome sequencing for improved genome assemblies

The rapid progress of the sequencing technology and bioinformatics was demonstrated at the recent Plant and Animal Genome meeting in ... Read more...

Bioinformatics Core announce their training courses for 2015

January 19, 2015

Bioinformatics Core (center aligned)

The Genome Center’s Bioinformatics Core facility has recently announced three training courses for 2015. Click on the links below for more details about the content of each course and for information on how to register:

Upcoming Talks and Events

Events on February 20, 2015
Seminar — Dr Hao Chen — Allele-specific copy number profiling by next-generation DNA sequencing
Starts: 9:00 am
Ends: February 20, 2015 - 10:00 am
Location: GBSF Room 4202
Description: Part of the Genome Center Structural and Functional Genomics Seminar Series


Abstract

The progression and clonal development of tumors often involve amplifications and deletions of genomic DNA. Estimation of allele-specific copy number, which quantifies the number of copies of each allele at each variant loci rather than the total number of chromosome copies, is an important step in giving a more complete portrait of tumor genomes and the inference of their clonal history. We propose a novel method, falcon, for finding somatic allele-specific copy number changes by next generation sequencing of tumors with matched normal. Falcon is based on a change-point model on a bivariate mixed Binomial process, which explicitly models the copy numbers of the two chromosome haplotypes and corrects for local allele-specific coverage biases. By using the Binomial distribution rather than a normal approximation, falcon more effectively pools evidence from sites with low coverage. We applied this method in the analysis of a pre-malignant colon tumor sample and late-stage colorectal adenocarcinoma from the same individual. The allele-specific copy number estimates obtained by falcon allow us to draw detailed conclusions regarding the clonal history of the individual’s colon cancer.
Events on March 4, 2015
Dr Janine LaSalle — Seminar — Mapping the Placental Methylome at the Interface of Genetics and Environment in Autism Risk
Starts: 12:00 pm
Ends: March 4, 2015 - 1:00 pm
Location: Center for Health and Technology room 1341, 4610 X St Sacramento
Description: Part of the Human Genomic Seminar Series