Welcome to the Genome Center

Established in 2003 the UC Davis Genome Center uses state-of-art-technologies to understand how the heritable genetic information of diverse organisms function in health and disease. The combination of cutting-edge research facilities, diverse service cores, and talented staff make the Genome Center a world class facility for genomics research and training.

Research that makes a difference

A sample of questions being addressed by the UC Davis Genome Center faculty and their collaborators:

  • How do variations in the human genome affect the risks of diseases such as cancer, coronary artery disease, and autism?
  • Do infection, diet, or stress serve as environmental triggers of Type 1 diabetes?
  • What novel, useful organisms will be discovered by sequencing microbes from extreme environments?
  • Can characterization of the small chemicals in algae lead to new biofuels?
  • How can we control diseases of important food crops?
  • How can plants be modified to increase their productivity and quality?
  • What changes can we make to proteins to enhance their performance?
  • Can we model and predict life’s basic processes?
  • How can we glean useful information from vast datasets?

News highlights

Please see the news page for all news items relating to the Genome Center.

Genome Center scientists sequence genomes of 59 salt-loving organisms to help our understanding of osmoadaptation

November 13, 2014

facciotti_paper.001A new paper published today in PLOS Genetics showcases the work of many people from the Genome Center (names in bold below indicate Genome Center personnel):

Phylogenetically Driven Sequencing of Extremely Halophilic Archaea Reveals Strategies for Static and Dynamic Osmo-response

Erin A. Becker, ... Read more...

Under Genome Center supervision, UC Davis team wins the grand prize in the 2014 iGEM competition

November 4, 2014

The annual iGEM (International Genetically Engineered Machine) competition in synthetic biology has been won by a team of students from UC Davis! The iGEM competition sees teams of undergraduates from around the world use a kit of biological parts to build devices capable of helping with real world problems. This years competition attracted almost 250 ... Read more...

Beautiful panorama of UC Davis campus featuring GBSF building

November 4, 2014

Alex Kozik from the Michelmore lab made this amazing panoramic photo by stitching together six different photos. Click on the image and then you will be able to zoom in to see a lot of detail.

Read more...

The processes of sex determination in persimmons are revealed by Genome Center researchers

October 30, 2014

Science paperWork by members of the Comai Lab in collaboration with researchers from Kyoto University in Japan have helped reveal the mechanism underlying sex determination in the persimmon fruit. Their paper, published in the journal Science, will greatly contribute to the understanding of the evolution of ... Read more...

Professor Jonathan Eisen shares his thoughts on Google Scholar

October 27, 2014

Google Scholar

Jonathan Eisen photographed in his office in the Genome building.

Professor Jonathan Eisen appeared today as an invited contributor to the Google Scholar blog. He wrote on the topic of Using Google Scholar ... Read more...

Genome Center Talks & Events

Events on November 21, 2014
Talk — Sharon Aviran — Inferring RNA structure from sequencing data and probabilistic models
Starts: 9:00 am
Ends: November 21, 2014 - 10:00 am
Location: GBSF room 4202
Description: GC structural and functional genomics focus group meeting.

Coffee and pastries will be provided

Abstract
Despite great interest in solving RNA secondary structures due to their impact on function, it remains an open problem to determine structure from sequence alone. Several high-throughput approaches to RNA structure determination have recently emerged, which facilitate parallel and high-resolution measurements of structural information for a multitude of distinct RNAs in a single experiment. One of these techniques, SHAPE-Seq, was the first to couple a chemistry-based approach to structure determination, called SHAPE, with next-generation sequencing of its DNA products. Following sequencing, an algorithmic pipeline recovers the desired information from the noisy measurements, representing a novel approach to rapid, consistent, and fully automated analysis of this new wealth of information. I will describe SHAPE-Seq and its model-based approach to analysis. I will then discuss several very recent and exiting breakthroughs in experimental structure determination along with the informatics challenges that they present. I will conclude by highlighting the role that model-based computer simulations can play in facilitating rational experiment design of these advanced and complex sequencing-based methods.